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Cancer

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Cancer refers to a disease/condition in which cells grow and multiply uncontrollably in one organ to form a tumor, and spreads to the other parts of the body. Tumors can either be cancerous or benign. As the name itself suggests, ovarian cancer is a type of cancer that develops in the ovaries. The female reproductive system contains two ovaries on each side of the uterus, which are responsible for producing eggs and estrogen.

Though not common, ovarian cancer causes more deaths among women than other types of cancers. In most cases, it is difficult to detect ovarian cancer in the early stages. Ovarian cancer goes undetected until it has spread to the pelvis, abdomen, and nearby areas.  In this advanced stage, the cancer is quite difficult to treat. However, early-stage ovarian cancer that is confined to the ovaries is more likely to be treated successfully.

Symptoms of Ovarian Cancer

As mentioned earlier, ovarian cancer is unlikely to be detected in the earlier stages as there may be fewer to no symptoms. The early symptoms may also resemble those of other conditions such as premenstrual syndrome and other bladder-related problems. However, it is important to consult with your medical practitioner if the symptoms persist. Some of the most common ovarian cancer symptoms include:

  • Immense pain or pressure in the pelvic area
  • Abnormal bloating
  • Pain in the back/abdomen
  • Unusually frequent/less frequent urination
  • Changes in bowel habits
  • Weight loss
  • Loss of appetite
  • Nausea
  • Shortness of breath
  • Fatigue
  • Irregular periods
  • Vaginal bleeding

The symptoms also tend to change when cancer spreads to other parts of the body. It is important to make an appointment with your doctor if any of these symptoms worry you, or if you have a family history of ovarian cancer.

Causes of Ovarian Cancer

Though there are no definitive causes that lead to ovarian cancer, there are several factors that can increase the risk of one being diagnosed with ovarian cancer. These risk factors include:

Age

The risk of developing ovarian cancer increases with age. Ovarian cancer mostly develops in women who have reached menopause. Around 50% of ovarian cancer cases are found in women above the age of 63.

Family history of cancer

Having a near family member with a history of ovarian cancer, breast cancer, or even colorectal cancer, can increase the risk of developing the condition. This is because cancer can be caused by an inherited mutation in certain genes.

Hormone replacement therapy

Women undergoing Hormone Replacement Therapy (HRT) after menopause is at an increased risk of developing ovarian cancer. The longer the Hormone Replacement Therapy is given, the higher the risk. However, the risk reduces when the treatment stops.

Reproductive history

Women who have undergone one or more full-term pregnancies are at a lower risk of developing ovarian cancer. Breastfeeding also contributes to reducing the risk of ovarian cancer. However, having children after the age of 35 or never having a full-term pregnancy can increase the risk.

Breast cancer

Women diagnosed with breast cancer or with a history of breast cancer are also at a higher risk of developing ovarian cancer. This is mostly due to the changes in the BRCA gene.

Obesity

Obesity has been linked to the risk of developing many types of cancer. Women with a Body Mass Index (BMI) of over 30 are more likely to develop breast cancer.

Androgens

Having high levels of androgens (male hormones), such as testosterone may increase the risk of ovarian cancer. Certain androgens lead to specific types of ovarian cancers.

Prevention of  Ovarian Cancer

Most women are likely to have one or more risk factors that may lead to ovarian cancer. Like most cancers, though there aren’t sure-shot ways to prevent ovarian cancer, you can work towards reducing and eliminating certain risk factors that may lead to the condition. Some of the precautions that can be taken to reduce the risk are:

Maintain a healthy weight

One of the most common causes/risk factors for all cancers is obesity. Ensure that you maintain a healthy weight and follow good dietary habits with an exercise routine to keep your Body Mass Index (BMI) in check.

Avoid HRT

Avoiding Estrogen Hormone Replacement Therapy after menopause can reduce the risk of developing the disease considerably.

Birth control pills

Using oral contraceptives, commonly known as birth control pills, decreases the risk of developing ovarian cancer. Talk to your healthcare provider about birth control pills and which ones may be right for you. However, birth control pills also have certain side effects and other associated risks, so discuss the advantages and disadvantages before taking them.

Gynecologic surgeries

Gynecologic procedures such as tubal ligation and hysterectomy may help in reducing the risk of certain types of ovarian cancer. However, these procedures have to be done only for valid medical conditions, and not just the reduce the risk of ovarian cancer.

Pregnancy and breastfeeding

Women who have had one or more full-term pregnancies before the age of 26 have a lower risk of developing ovarian cancer as compared to women who have not. Breastfeeding helps in lowering the risk even further.

If you or your loved one has been diagnosed with ovarian cancer, you can discuss with your medical practitioner about the various treatment methods. You need to understand the pros and cons of each treatment option before finalizing one. Some of the most common treatment options for ovarian cancer include surgery to remove the tumors, radiation therapy, chemotherapy, hormone therapy, and targeted therapy. Treatment can also vary depending on the type and stage of ovarian cancer.

Though there are no definitive ways to prevent ovarian cancer, it is important to be aware and fully informed of the symptoms. Approach your doctor or healthcare provider immediately, if you notice one or more of these symptoms in you or your loved ones; as early detection saves lives. You can also work towards reducing certain risks associated with the disease by following a healthy lifestyle and taking precautions. Remember, prevention is better than cure!

Ovarian cancer is the third most common gynecological cancer in Indian women. and it causes more deaths than any other cancer of the female reproductive system. While the rate at which ovarian cancer can be fatal is 1 in 108, it is a hopeful statistic that the rate at which women are diagnosed with ovarian cancer has been slowly falling over the past 20 years.

What is Ovarian Cancer?

The ovaries are small organs located on either side of the uterus. Their function is to produce eggs for reproduction. Ovarian cancer can form in different parts of the ovary.

Germ cells are the cells that become eggs in the ovaries, stromal cells make up the substance of the ovary,  and epithelial cells are the outer layer of the ovary. Ovarian cancer can start in either of these cells.

Genetic mutations that are responsible for cancer may be hereditary or they can be acquired. Doctors studying ovarian cancer are trying to identify which of these mutations are responsible for cancer. Ovarian cancer can develop in a woman of any age, although it is most commonly diagnosed in postmenopausal women between the ages of 55 and 64

How is Ovarian Cancer Diagnosed?

Pelvic Exam

Pelvic exams are routine exams done by a primary-care doctor or an obstetrician-gynecologist. The doctor feels for an enlarged ovary and any signs of fluid in the abdomen by inserting two gloved fingers into the vagina and places the other hand on the abdomen. This helps the doctor to check the size, shape, and consistency of the ovaries and uterus.

A pelvic exam may also help to detect conditions such as pelvic inflammatory disease, cervical polyps, uterine fibroids, genital warts, bacterial vaginosis, etc.

While detecting ovarian cancer through a pelvic exam is rare. The doctor may ask the patient to take a few more tests to confirm a diagnosis.

Imaging tests

Transvaginal ultrasound:

Imaging tests such as a transvaginal ultrasound uses high-energy sound waves to detect abnormalities like ovarian tumors, etc. These abnormalities may appear as solid or as a fluid-filled cyst. This imaging test also helps visualize the size of the ovary along with other irregularities in the reproductive system, i.e, the vagina, the bladder, the fallopian tubes.

The doctor or ultrasound technician inserts a probe into the vagina to capture images of the organs and tissues.

Ovarian biopsy: While ultrasound can detect an irregularity, it can’t determine whether the mass is cancerous or not. This requires a biopsy.

A CT scan or a Computed tomography is used to locate a tumor before surgery. It can also help determine tumor size, and detect whether or not the other organs are affected. An MRI or magnetic resonance imaging has greater soft tissue contrast than a CT scan and hence is extremely useful in detecting tumors or recurrences in other organs in the body. This is why an MRI is often used in combination with other tests as part of the evaluation process.

Positron emission tomography-computed tomography or a (PET/CT) scan is sometimes used to help diagnose ovarian, fallopian tube, or peritoneal cancer. The scan can measure a tumor’s ability to use a type of sugar: glucose. Faster growing cells utilize more sugar and show up brighter on this imaging test, hence indicating the presence of cancer.

Treatment of Ovarian Cancer

The treatment of ovarian cancer depends on factors such as the type of ovarian cancer, the stage at which it is, and whether or not one wants to have children in the future.

Surgery

Once the diagnosis and the stage of the cancer are determined, cancer can be removed via surgery. During the procedure, the surgeon will remove all the tissue that contains cancer. The doctor might also ask the patient to take a biopsy to see if cancer has spread.

If one wants to have children in the future but has stage 1 cancer, the surgery can include the following modifications:

  • removal of the ovary that has cancer
  • biopsy of the other ovary
  • biopsies of other tissues and collection of fluid inside of the abdomen for further evaluation
  • removal of the fatty tissue, or omentum connecting to the abdominal organs
  • removal of abdominal and pelvic lymph nodes

Advanced ovarian cancer surgery

If one has stage 2.3 or 4 cancer, and one does not want to have children in the future, the surgery is more extensive.

The procedure includes the complete removal of areas and organs involved with cancer

Removal of:

  • The Uterus
  • Both the ovaries and fallopian tubes
  • The omentum
  • As much tissue that has cancer cells

And biopsies of any tissue that might be cancerous.

Chemotherapy

Chemotherapy is usually the next step after surgery. Medications can be given through the abdomen or intravenously.

Some side effects of chemotherapy can include:

  • nausea
  • vomiting
  • hair loss
  • fatigue
  • problems sleeping

Ovarian cancer is a serious condition that comes with a physical as well as an emotional toll on the patient. It is highly advisable that one that is experiencing the symptoms mentioned above immediately consult their doctor to undergo the proper diagnosis. It is important to understand every aspect of the condition before going into treatment.

Oral Cancer, as the name itself suggests, refers to cancerous growth in any part of the mouth (oral cavity). It falls under a category of cancers called Head and Neck Cancers. Also known as Mouth Cancer or Oral Cavity Cancer, this type of cancer occurs on the lips, gums, hard and soft palates, inner cheek lining, tongue, the roof of the mouth, under the tongue, and throat. Mouth Cancer can be life-threatening if not diagnosed and treated immediately. Getting quarterly or biannual dental checkups can help in the early detection and treatment of oral cancer.

Make an appointment with your doctor as soon as you spot symptoms such as a lip/mouth sore, a white or red spot in your mouth, a lump in the mouth, difficulty/pain while swallowing, or pain in the mouth. The doctor will ensure if the symptoms are due to other causes such as an infection or any other underlying condition before diagnosing oral cancer.

Who are at risk of getting diagnosed with Oral Cancer?

According to the American Cancer Society, men are at a higher risk of getting diagnosed with oral cancer than women. Oral cancer is most prevalent in men over the age of 40-50. Some of the risk factors that lead to the development of oral cancer include:

Smoking: People who have the habit of frequently smoking cigarettes, cigars, or pipes are more likely to develop oral cancer as compared to people who do not smoke.

Other forms of tobacco use: Apart from smoking, people who consume tobacco by snuffing and chewing are prone to oral cancer in the gums, lips, and inner cheeks.

Alcohol consumption: People who consume excessive amounts of alcohol are six times more likely to get diagnosed with oral cancer as compared to non-drinkers.

Family History: If one or more of your family members are diagnosed with oral cancer, you are more susceptible to the disease.

Weak immune system: It is your immune system that helps your body fight against various illnesses. If your immune system is weak due to certain conditions, you are prone to oral cancer, along with other diseases.

Human Papillomavirus (HPV): The Human Papillomavirus (HPV) is a sexually transmitted virus that could be a major contributing factor for the development of oral cancer.

What are the precancerous conditions of the oral cavity?

A precancerous condition is a condition that involves abnormal cells which lead to an increased risk of developing cancer. Depending on the type of cancer, the precancerous conditions can be few or many.

In oral cancer, precancerous conditions are the changes that take place in the cells of the mouth. These conditions are not developed into cancer yet. But, if left untreated, there are higher chances that these abnormal changes or mutations might advance into oral cancer.

Oral cancer has the two most common precancerous conditions. They are:

Leukoplakia:

Leukoplakia is an unusual grey or white patch that is visible on the tongue, the gums, the inner cheek linings, or the floor of your mouth. If one has leukoplakia, it is not necessary that he/she will develop oral cancer. Depending on the size and shape of the abnormal cells, this precancerous condition may develop into oral cancer.

Erythroplakia:

Erythroplakia is an abnormal red patch or a group of red spots that is visible on the mucous membrane in the mouth, with no definitive cause. This precancerous condition has higher chances of developing into oral cancer as compared to Leukoplakia. Around 50% of these conditions advance into Squamous Cell Carcinoma.

How can you prevent oral cancer?

Though there are no proven measures to prevent oral cancer. However, there are certain precautions one can take to reduce the risk. They are as follows:

Stopping the consumption of tobacco: As mentioned above, tobacco usage is one of the most common risk factors that lead to oral cancer. If you are a regular consumer of tobacco, put a stop to it. Smoking, chewing, or snuffing tobacco is dangerous as it exposes the cells in your mouth to cancer-inducing chemicals.

Moderate alcohol consumption: Excessive alcohol consumption can weaken the cells in your mouth, making you vulnerable to oral cancer. Hence, alcohol should be consumed in moderate amounts or to be completely avoided to lower the risk of mouth cancer.

Avoid excessive sun exposure: Protect the skin on your lips from excessive sunlight by applying lip balm with sun protection as a part of your regimen. You can also wear a broad-rimmed hat when you step out and stay in the shade as much as possible.

The first step to fighting oral cancer is to be mindful of the risk factors and symptoms. Although oral cancer can become fatal if not treated on time, taking precautions to reduce the risk will help keep oral cancer at bay. Have a regular quarterly/biannual check-up with your dentist and ensure proper oral hygiene, because prevention is better than cure!

Cancer is a disease in which cells divide and multiply uncontrollably, invading nearby tissues and organs. This happens when mutations are caused in the genes that control the growth of the cells. Cancer occurs when the cells grow uncontrollably, collectively forming a mass of tissue called a tumor. These tumors can either be cancerous or non-cancerous.

Oral cancer, also known as mouth cancer or oral cavity cancer, falls under a category of cancers called Head and Neck Cancers. Oral cancer occurs when there is a cancerous growth in the mouth or the oral cavity. Oral cancer usually occurs in the lips, tongues, cheeks, throat, hard and soft palate, the roof of the mouth, and on the floor of the mouth (under the tongue). People above the age of 40 are more susceptible to oral cancer.

Oral cancer usually begins in the squamous cells (flat, thin cells in the lining of the lips and inside the mouth). A majority of oral cancers are diagnosed to be Squamous Cell Carcinoma.

What are the Symptoms of Oral Cancer?

The diagnosis and treatment of oral cancer would be easier if one is aware of the symptoms and the signs of oral cancer. Some of the most common symptoms of oral cancer are:

  • A sore in the mouth or on the lip that doesn’t heal for a long time
  • Mass or lumpy growth anywhere in the mouth
  • A white or reddish patch inside the mouth
  • Unexplained bleeding
  • Loose teeth
  • Pain or difficulty in swallowing
  • Earache
  • Mouth ache
  • A lump in the neck
  • Numbness/tenderness in any area of the mouth, face, or neck
  • Sore throat
  • Stiffness or pain in the jaw
  • Drastic weight loss

Looking out for these symptoms and getting them checked immediately would help in effectively treating oral cancer. It is important to make an appointment with your doctor or dentist if you have one or more of these symptoms. Some of these symptoms may indicate another condition/disease/illness apart from oral cancer. Your doctor will look into the symptoms and rule out every other possibility before recommending tests for oral cancer.

How is Oral Cancer Diagnosed?

There are several procedures involved in diagnosing Oral Cancer. The first step is to gauge the reason behind the symptoms to rule out other underlying conditions and ensure that the symptoms are due to oral cancer. Once the patient has been diagnosed with oral cancer, the doctor might perform a further diagnosis to determine the type of cancer – invasive/non-invasive and the extent to which it has spread. Some of the tests and procedures used to diagnose oral cancer include:

Physical Exam: Your doctor will closely examine your lips and mouth to check for abnormalities, especially the roof and floor of your mouth, the back of your throat, your tongue, gums, cheeks, and the lymph nodes on the neck.

Biopsy: In case of a suspicious/infected area in the mouth, your doctor may take a sample of your tissue using a cutting tool or a needle for laboratory testing. This procedure is known as a biopsy.

Once the patient is diagnosed with oral cancer, the doctor will determine the extent (stage) of oral cancer, and how much it has spread. To determine this, the doctor may turn to one of these procedures:

Endoscopy: During this procedure, the doctor may insert a small camera with a light attached to a tube down your throat to determine how cancer has spread beyond the mouth.

X-Ray: The doctor might also suggest an x-ray to check if the cancerous cells have spread to the chest or lungs.

CT scan: The Computed Tomography (CT) scan is an imaging technique that uses a series of x-ray images to get detailed images of the body. The CT scan helps reveal any tumors in the mouth, throat, neck, and lungs.

PET scan: The Positron Emission Tomography (PET) scan is an imaging technique that uses a special dye that contains radioactive tracers. This is to determine if cancer has traveled to the lymph nodes or other organs.

MRI scan: Magnetic Resonance Imaging (MRI) uses a large magnet to generate images of the body using radio waves. This method also helps to determine the extent to which cancer has spread.

Once diagnosed, Oral cancer is determined in 4 stages.

Stage I: Where the tumor is 2cm or smaller and cancer hasn’t spread to the lymph nodes.

Stage II: Where the tumor is between 2-4cm, and cancer hasn’t spread to the lymph nodes.

Stage III: Where the tumor is larger than 4cm but hasn’t spread to the lymph nodes; or tumor is of any size but has spread to one lymph node.

Stage IV: Where the tumors are in any size and the cancerous cells have spread to the lymph nodes, nearby tissues, and other organs.

Oral Cancer Treatment

Depending on the location, stage, and nature of oral cancer, the treatment options will differ. Based on the analysis of your doctor, you may have to undergo one form of treatment or a combination of cancer treatments. Some of the most common and effective treatment options are:

Surgery: If the cancer is in an early stage, the surgeon may cut off the tumor and a margin of the healthy tissues that surround that area to ensure that all the cancerous cells have been removed. Minor surgery is required for small cancerous cells, but, larger tumors require an extensive procedure.

Radiation Therapy: This therapy uses high-energy radiation beams at the tumor. If the cancer is in an advanced stage, the doctor might use a combination of chemotherapy and radiation therapy.

Chemotherapy: This treatment uses chemicals/drugs to kills cancerous cells. The drug is usually administered through an Intravenous (IV) line or orally.

Targeted Therapy: This therapy treats mouth cancer by altering specific aspects of the cancerous cells that interfere with their growth.

Immunotherapy: This treatment uses your immune system to fight cancer cells. Cancerous cells produce proteins that bind the cells in the immune system. This therapy works by interfering with that process.

Though there are several treatment options to treat oral cancer, the best way to fight it would be by reducing the risk and following a healthy oral regimen. Early detection is the key to fight any disease. So be aware of the symptoms and check with your doctor as soon as you see any signs that may develop into oral cancer.

The term cancer can be overwhelming for the majority of people. It can be physically as well as emotionally too much to take in for an individual along with people around them. Hence understanding cancer is very important because having the right information can lead to taking steps at the right time to cut down your risk of cancer. Cancer is a name given to a collection of diseases that are related. It causes body cells to divide rapidly and in some cases can also affect the surrounding tissues. The rapid creation of abnormal cells that grow beyond their boundaries is one of the most defining features of cancer, which can then invade other parts of the body; this process is referred to as Metastasis. The primary cause of death in cancer is Metastases.

Due to advanced technology and medicine, the treatments are constantly improving. With proper diagnosis and treatment, many cancers have a high cure rate. Between 30-50 % of cancer cases can be prevented by avoiding the risk factors and implementing existing prevention strategies.

Cancer is the leading cause of death in the world. After breast cancer, Lung cancer is the second most common type of cancer in the world. It is also one of the most common causes of cancer death in the year 2020. According to World Health organization Statistics, there were 2.21 million cases in 2020 worldwide in which there was 1.80 million death. 

What is Lung cancer?

The two sponge-like organs in the chest are called lungs. The right lung has three sections called upper, middle, and lower lobes. The left lung has two lobes upper and lower lobes, left lung is smaller because the heart takes up more space on that side of the body. When we breathe, through the trachea (windpipe) the air inhaled goes into the lungs. The Trachea divides into tubes called Bronchi, which enters the lungs and is further divided into smaller Bronchi called Bronchioles. At the end of the Bronchioles, there are tiny sacs called alveoli. The main function of Alveoli is absorbing oxygen into the blood and removing carbon dioxide from the blood when you exhale.

Lung cancer can start in any part of the lungs or airways which includes the windpipe the main airway or the lungs themselves. When there is an uncontrolled growth of abnormal cells inside one or both lungs the cells grow to form a tumor. 

The major risk factor for lung cancer is smoking though not everyone who develops lung cancer has a history of smoking. Lung cancer can be fatal but with proper diagnosis and treatment, the outlook to it could differ.

Types of Lung cancer

Cancer that starts growing in the lungs is called primary lung cancer. If cancer spreads from other parts of your body to the lungs is called Secondary lung cancer.

There are 2 types of Primary lung cancer: 

  • Small cell lung cancer (SCLC) 
  • Non-small cell lung cancer (NSCLC) 

Small cell lung cancer 

Small cell lung cancer is a fast-growing and more aggressive form of lung cancer. Cancer grows and spreads rapidly traveling to other parts of the body or metastasize more easily. Due to this, the condition is usually diagnosed after cancer has spread throughout the body, making recovery doubtful. But if it is detected in an early stage it may be treated effectively before cancer spreads. 

Symptoms for Small cell lung cancer 

SCLC is usually asymptomatic which means it doesn’t show symptoms. Once there are visible symptoms it often indicates that cancer has started growing and has infected other parts of the body. 

Symptoms are: 

  • Wheezing 
  • Shortness of breath 
  • Bloody mucus for the lungs 
  • Fatigue 
  • Weight loss 
  • A persistent cough 

If you notice any symptom connect to a doctor immediately. 

Non-small cell lung cancer 

It is the most common and less aggressive than Small cell lung cancer which means it doesn’t spread and grow rapidly. 

NSCLC can be treated successfully with surgery, chemotherapy, and other treatments. 

Smoking is the leading cause of NSCLC and other types of cancer. 

Symptoms for Non-small cell lung cancer

  • Hoariness
  • Fatigue
  • Coughing up phlegm or mucus
  • Chest pain
  • Shortness of breath
  • Cough

 You need to note that some of these symptoms may occur due to other reasons as well.

Risk factors for lung cancer

Anything that increases a person’s chance of getting cancer is classified as a risk factor. Some risk factors can be changed like smoking, but others like family history or a person’s age cannot be changed. ­­­­­

Some of the risk factors are: 

  • Smoking- Smoking remains the number one reason for developing lung cancer. The longer you smoke greater the risk. 
  • Passive smoking: If you are a non-smoker who hangs out with people who smoke, you are still at risk of developing lung cancer. 
  • Air pollution: Air pollution raises the risk of lung cancer especially in cities. 
  • Personal or family history: If you had relatives who suffered from lung cancer then the probability of you developing it increases. 
  • Exposure to Radon: A naturally occurring radioactive gas that results from the breakdown of uranium in soil and rocks is Radon. Breathing it in can expose you to a small amount of radiation. 

We should be careful and consider all these risk factors to reduce the chances of developing lung cancer.

Coping with a cancer diagnosis can be stressful and difficult. Learn about your condition and treatment by talking to your doctor about it. Online resources can also be useful to understand and gain a sense of control over the situation.

Lung cancer can be fatal but early diagnosis often have a good chance of survival. People who are at high risk of developing lung cancer should consider getting regular screenings. People who are concerned with the risk factor should talk to a healthcare professional.